DCC Mediated Direct Amidation of NSAID Naproxen, Ibuprofen and Ketoprofen with Secondary Amines

Direct and atom-economical amidation of nonsteroidal anti-inflammatory drugs naproxen ibuprofen ketoprofen with a variety secondary amines was effected using commercially available DCC under mild open-air conditions. These prodrug amides were obtained in good to moderate yields ranging between 30–90 %.